Calpain 1

Calpain 1

• Gene Name: [CAPN1]
• NCBI Gene ID: 823
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.
• Other Gene Names: [CAPN1; CAPN1; CANP; muCL; CANP1; SPG76; CANPL1; muCANP; CANPL1; CANP 1; muCANP]
• Short Name: [Calpain 1]
• Other Product Names: [calpain 1, (mu/I) large subunit, isoform CRA_c; Calpain-1 catalytic subunit; calpain-1 catalytic subunit; calpain 1; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain]
• NCBI GI Number: 119594774
• NCBI Accession Number: EAW74368.1
• Uniprot Accession Number: P07384