HLA-DRB (MHC II)

• Gene Name:

  [HLA-DRB]

• NCBI Gene ID:

  3123

• Reactivity:

  Human, Monkey
  Does not react with Mouse.

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  This MAb reacts with a 28kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.

• Other Gene Names:

  [HLA-DRB1; HLA-DRB1; SS1; DRB1; HLA-DRB; HLA-DR1B; HLA-DRB2]

• Short Name:

  [HLA-DRB]

• Other Product Names:

  [major histocompatibility complex, class II, DR beta 1; HLA class II histocompatibility antigen, DRB1-15 beta chain; major histocompatibility complex, class II, DR beta 1; major histocompatibility complex, class II, DR beta 1; DW2.2/DR2.2; MHC class II antigen DRB1*15]

• NCBI GI Number:

  155030211

• NCBI Accession Number:

  NP_002115.2

• NCBI GB Accession Number:

  NP_002115.2

• Uniprot Accession Number:

  P01911