ERCC1/RAD10 (Tumor Progression Marker)

• Gene Name: [ERCC1]
• NCBI Gene ID: 2067
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a protein of 110kDa, identified as Excision Repair Cross Complementing 1 (ERCC1). It is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.
• Other Gene Names: [ERCC1; ERCC1; UV20; COFS4; RAD10]
• Short Name: [ERCC1/RAD10]
• Other Product Names: [DNA excision repair protein ERCC-1 isoform 3; DNA excision repair protein ERCC-1; DNA excision repair protein ERCC-1; ERCC excision repair 1, endonuclease non-catalytic subunit]
• NCBI GI Number: 260593725
• NCBI Accession Number: NP_001159521.1
• NCBI GB Accession Number: NP_001159521.1
• Uniprot Accession Number: P07992