E-Cadherin (CDH1)/CD324 (Intercellular Junction Marker)

• Gene Name:

  [CDH1]

• NCBI Gene ID:

  999

• Reactivity:

  Human.
  Does not react with Mouse and Rat. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as ?-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help of mesothelioma.

• Other Gene Names:

  [CDH1; CDH1; UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324; CDHE; UVO; E-cadherin]

• Short Name:

  [E-Cadherin (CDH1)/CD324]

• Other Product Names:

  [cadherin-1 isoform 2; Cadherin-1; cadherin-1; cadherin 1; CAM 120/80; Epithelial cadherin; E-cadherin]

• NCBI GI Number:

  953768348

• NCBI Accession Number:

  NP_001304113.1

• NCBI GB Accession Number:

  NM_001317184.1

• Uniprot Accession Number:

  P12830