NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)

NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)

• Gene Name: [NKX2.2]
• NCBI Gene ID: 4821
• Reactivity: Human. Others not known.
• Storage Conditions: Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential small round cell tumors.
• Other Gene Names: [NKX2-2; NKX2-2; NKX2B; NKX2.2; NKX2.2; NKX2B]
• Short Name: [NKX2.2]
• Other Product Names: [homeobox protein Nkx-2.2; Homeobox protein Nkx-2.2; homeobox protein Nkx-2.2; NK2 homeobox 2; Homeobox protein NK-2 homolog B]
• NCBI GI Number: 4505401
• NCBI Accession Number: NP_002500.1
• NCBI GB Accession Number: NM_002509.3
• Uniprot Accession Number: O95096