Alpha Synuclein Oligomers (Dopamine HCL Stabilized)

• Background:

  Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Dopamine inhibits alpha synuclein fibrillogenesis leading to oligomer accumulation in vitro (7), (8) and in vivo (9), (10).

• Description:

  Human Recombinant Alpha Synuclein Oligomers (Dopamine HCL Stabilized)

• Product Name Alternative:

  Alpha synuclein protein, Alpha-synuclein oligomer, Alpha synuclein protein oligomer, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, Alpha synuclein oligomers, Alpha Synuclein Protein Oligomers, SYN protein, Parkinson's disease familial 1 Protein

• UNSPSC:

  12352202

• Gene ID:

  6622

• Swiss Prot:

  P37840

• Accession Number:

  NP_000336.1

• Cellular Locus:

  Cytoplasm | Membrane | Nucleus

• Host:

  E. coli

• Origin Species:

  Human

• Target:

  Alpha Synuclein Oligomers

• Conjugation:

  No Tag

• Applications:

  WB, SDS-PAGE, In vivo assay, In vitro assay

• Purification Method:

  Ion-exchange Purified. Monomeric alpha synuclein was removed via filtration.

• Concentration:

  2 mg/ml

• Purity:

  >95%

• Weight:

  0.5

• Length:

  Full length

• Buffer:

  PBS pH 7.4

• Molecular Weight:

  ~14.46kDa

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

• Additionnal Information:

  Monomer source is catalog# SPR-316.

• References & Citations:

  1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757. 7. Conway, K.A. et al. (2001) Science 294:1346-1349. 8. Norris, E.H. et al. (2005) J Biol Chem. 280:21212-21219. 9. Mazulli, J.R. et al. (2006). J Neurosci. 26:10068-10078. 10. Mazulli, J.R. et al. (2007). J Biol Chem. 282:31621-31630.