PROTAC MPS1 degrader 2

• UNSPSC Description:

  PROTAC MPS1 degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA and AURKB, with DC50s of 42.0, 2.1 and 154.0 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168545); Black: linker (HY-N0420); Blue: ligand for E3 ligase (HY-10984)[1].

• Target Antigen:

  Aurora Kinase; Mps1; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-mps1-degrader-2.html

• Smiles:

  O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC(N4CCN(C5=CC=C(NC6=NC(NC7=CC=CC=C7S(=O)(C(C)C)=O)=C8N=CNC8=N6)C=C5)CC4)=O

• Molecular Weight:

  847.90

• References & Citations:

  [1]Sflakidou E, et, al. Development of 2-Aminoadenine-Based Proteolysis-Targeting Chimeras (PROTACs) as Novel Potent Degraders of Monopolar Spindle 1 and Aurora Kinases. ACS Pharmacol. Transl. Sci. 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported