Methotrexate-γ-aspartate

Methotrexate-γ-aspartate

• CAS Number: 64801-58-7
• UNSPSC Description: Methotrexate-γ-aspartate is a Ll210 cell dihydrofolate reductase inhibitor. Methotrexate-γ-aspartate is apparently more resistant to enzymic cleavage than is methotrexate-y-glutamate. Methotrexate-γ-aspartate can be used in antibody-targeted liposomes and is promising for research of leukemic[1].
• Target Antigen: Dihydrofolate reductase (DHFR)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/methotrexate-γ-aspartate.html
• Smiles: NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CC(O)=O)=O)=O)C)C=N2
• Molecular Weight: 569.53
• References & Citations: [1]Sirotnak FM, et al. Growth inhibitory, transport and biochemical properties of the gamma-glutamyl and gamma-aspartyl peptides of methotrexate in L1210 leukemia cells in vitro. Biochem Pharmacol. 1978;27(14):1821-5.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported