NDR2 rabbit pAb

• Description:

  Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L. function: Involved in the regulation of structural processes in differentiating and mature neuronal cells. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. similarity: Contains 1 AGC-kinase C-terminal domain. similarity: Contains 1 protein kinase domain. subcellular location: Associated with the actin cytoskeleton. subunit: Homodimeric S100B binds two molecules of STK38L (By similarity). Interacts with MOB1 and MOB2. tissue specificity: Ubiquitously expressed with highest levels observed in the thymus.

• Synonyms:

  STK38L; KIAA0965; NDR2; Serine/threonine-protein kinase 38-like; NDR2 protein kinase; Nuclear Dbf2-related kinase 2

• Gene ID:

  23012

• UniProt:

  Q9Y2H1

• Cellular Locus:

  Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthesized peptide derived from NDR2 . at AA range: 380-460

• Clonality:

  Polyclonal

• Validated Applications:

  WB, IHC, IF, ELISA

• Stability:

  1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000.IHC-p:1:50-300 ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  54kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.