Nesprin-3 rabbit pAb

• Description:

  Function: Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which theters the nucleus to the cytoskeleton by binding PLEC1/Plectin which can associate with the intermediate filament system. similarity: Belongs to the nesprin family. similarity: Contains 1 KASH domain. similarity: Contains 2 spectrin repeats. subcellular location: Located at the rough reticulum endoplasmic (RER) in some cells. subunit: Interacts with actin-binding domain of PLEC1/plectin.

• Synonyms:

  SYNE3; C14orf49; Nesprin-3; Nuclear envelope spectrin repeat protein 3

• Gene ID:

  161176

• UniProt:

  Q6ZMZ3

• Cellular Locus:

  Nucleus outer membrane ; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human C14orf49. AA range:169-218

• Clonality:

  Polyclonal

• Validated Applications:

  WB, IF, ELISA

• Stability:

  1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight:

  115kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.