PP2Cε rabbit pAb

• Description:

  The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],

• Synonyms:

  PPM1L; PP2CE; Protein phosphatase 1L; Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon; PP2C-epsilon

• Gene ID:

  151742

• UniProt:

  Q5SGD2

• Cellular Locus:

  Membrane ; Single-pass type I membrane protein.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human PPM1L. AA range:119-168

• Clonality:

  Polyclonal

• Validated Applications:

  WB, IHC

• Stability:

  1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000;IHC-p 1:50-300

• Molecular Weight:

  48kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.