SOCS-1 rabbit pAb

• Description: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of Cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of Cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of Cytokine receptors, and takes part in a negative feedback loop to attenuate Cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008],
• Synonyms: SOCS1; SSI1; TIP3; Suppressor of cytokine signaling 1; SOCS-1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3
• Gene ID: 8651
• UniProt: O15524
• Cellular Locus: Nucleus. Cytoplasmic vesicle. Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: The antiserum was produced against synthesized peptide derived from human SOCS-1. AA range:49-98
• Clonality: Polyclonal
• Validated Applications: IF, WB, IHC, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300
• Molecular Weight: 38kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.