Cleaved-Integrin α6 LC (E942) rabbit pAb

• Description:

  Integrin subunit alpha 6 (ITGA6) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

• Synonyms:

  ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f

• Gene ID:

  3655

• UniProt:

  P23229

• Cellular Locus:

  Cell membrane ; Single-pass type I membrane protein. Cell membrane ; Lipid-anchor.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human ITGA6. AA range:923-972

• Clonality:

  Polyclonal

• Validated Applications:

  WB, ELISA

• Stability:

  1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight:

  28kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.