QAQ (dichloride)

• UNSPSC Description:

  QAQ dichloride, a photoswitchable voltage-gated Nav and Kv channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain[1][2].

• Target Antigen:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/qaq-dichloride.html

• Purity:

  99.30

• Solubility:

  DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(NC1=CC=C(/N=N/C2=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C2)C=C1)C[N+](CC)(CC)CC.[Cl-].[Cl-]

• Molecular Weight:

  567.59

• References & Citations:

  [1]Timm Fehrentz, et al. Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers. Chembiochem. 2012 Aug 13;13(12):1746-9.|[2]Alexandre Mourot, et al.Photochromic Potassium Channel Blockers: Design and Electrophysiological Characterization. Methods Mol Biol. 2013;995:89-105.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported