Spectinomycin (sulfate hydrate)

Spectinomycin (sulfate hydrate)

• CAS Number: 64058-48-6
• UNSPSC Description: Spectinomycin sulfate hydrate is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin sulfate hydrate acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin sulfate hydrate is also a noncompetitive inhibitor of td intron RNA with an Ki value of 7.2 mM[1]-[5].
• Target Antigen: Antibiotic; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/spectinomycin-sulfate-hydrate.html
• Smiles: CN[C@@H]1[C@]2([H])[C@]([C@H]([C@@H]([C@@H]1O)NC)O)([H])O[C@@]3([H])[C@@](O2)(C(C[C@H](O3)C)=O)O.O=S(O)(O)=O.O.O.O.O
• Molecular Weight: 502.49
• References & Citations: [1]Davies J, et al. Inhibition of protein synthesis by spectinomycin. Science. 1965 Sep 3;149(3688):1096-8.|[2]Brink MF, et al. Spectinomycin interacts specifically with the residues G1064 and C1192 in 16S rRNA, thereby potentially freezing this molecule into an inactive conformation. Nucleic Acids Res. 1994 Feb 11;22(3):325-31.|[3]Park IK, et al. Spectinomycin inhibits the self-splicing of the group 1 intron RNA. Biochem Biophys Res Commun. 2000 Mar 16;269(2):574-9.|[4]Madhura DB, et al. Pharmacokinetic profile of spectinomycin in rats. Pharmazie. 2013 Aug;68(8):675-6.|[5]Khan EA, et al. Safety evaluation study of lincomycin and spectinomycin hydrochloride intramuscular injection in chickens. Toxicol Rep. 2022 Jan 29;9:204-209.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported