CDK2 degrader 1

• CAS Number:

  3036604-59-5

• UNSPSC Description:

  CDK2 degrader 1 (Compound 3) is an orally active cyclin-dependent kinase 2 (CDK2) degrader based on PROTAC technology. CDK2 degrader 1 binds to cereblon to induce ubiquitination and subsequent proteasomal degradation of the CDK2. CDK2 degrader 1 is used in the research of a wide range of cancers (Red: spiro[3.3]heptan-2- ylmethyl carbonochloridate; Blue: N,N-diisopropylethylamine; Black: linker)[1].

• Target Antigen:

  CDK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cdk2-degrader-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  [H][C@](C1)(CC2)C[C@]2([H])[C@@H]1COC(NC3CN(C4=CC(F)=C(C5C(NC(CC5)=O)=O)C(F)=C4)C3)=O

• Molecular Weight:

  447.47

• References & Citations:

  [1]Fasching B, et al. Compounds that mediate protein degradation and methods of use thereof[J]. US patent WO2023069700A1, 2022.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported