CMPD-39

CMPD-39

• CAS Number: 2242582-40-5
• UNSPSC Description: CMPD-39 is a selective USP30 inhibitor with an IC50 of 0.02 μM. CMPD-39 increases protein ubiquitination and accelerates mitophagy[1].
• Target Antigen: Deubiquitinase
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/usp30-inhibitor-18.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC(C)(C)NS(=O)(C1=CC=C(C=C1)NC([C@@H](NC(C2=CC=C(C=C2)F)=O)CC3=CC=CC=C3)=O)=O
• Molecular Weight: 497.58
• References & Citations: [1]Arthur F Kluge, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2655-2659.|[2]Rusilowicz-Jones EV, Barone FG, Lopes FM, et al. Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy. Life Sci Alliance. 2021;5(2):e202101287.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported