STAT3-IN-36

• CAS Number:

  3055766-74-7

• UNSPSC Description:

  STAT3-IN-36 (compound 11g) is a triple-target inhibitor targeting LRPPRC, STAT3, and CDK1 with anticancer activity. STAT3-IN-36 binds to LRPPRC, STAT3, and CDK1, exerting a stronger anticancer effect than TMF (HY-N6818) or Capecitabine (HY-B0016). STAT3-IN-36 inhibits HGC27 cells with IC50 1.8 μM.[1].

• Target Antigen:

  STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/stat3-in-36.html

• Smiles:

  O=S(C1=C(OC)C=C(OC)C2=C1OC(C3=CC=C(OC)C(S(=O)(NC4=CC=C(F)C=C4)=O)=C3)=CC2=O)(NC5=CC=C(F)C=C5)=O

• Molecular Weight:

  658.65

• References & Citations:

  [1]Wu R, et al. Design, synthesis, and biological evaluation of novel 5,7,4'-trimethoxyflavone sulfonamide-based derivatives as highly potent inhibitors of LRPPRC/STAT3/CDK1. Bioorg Chem. 2024 Dec;153:107878.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported