HIF-1α-IN-2 (hydrochloride)

• UNSPSC Description:

  HIF-1α-IN-2 hydrochloride is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 hydrochloride suppresses HIF-1α expression by blocking transcription and protein translation[1].

• Target Antigen:

  HIF/HIF Prolyl-Hydroxylase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hif-1α-in-2-hydrochloride.html

• Purity:

  99.16

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC1=NC(C2=CC(NC3=CC(C)=NC4=CC(OC)=CC=C34)=CC=C2)=CS1.Cl

• Molecular Weight:

  397.92

• References & Citations:

  [1]Wu YC, et al. Synthesis and evaluation of biarylquinoline derivatives as novel HIF-1α inhibitors. Bioorg Chem. 2022;121:105681.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported