5-Carboxamidotryptamine

• CAS Number:

  74885-09-9

• UNSPSC Description:

  5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist[1][2][3][4]. 5-Carboxamidotryptamine has a Ki value of 4.6 nM for cloned human 5-HT5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice[3][4].

• Target Antigen:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/5-carboxamidotryptamine.html

• Smiles:

  O=C(C1=CC2=C(NC=C2CCN)C=C1)N

• Molecular Weight:

  203.24

• References & Citations:

  [1]Saxena PR,et al. Characterization of 5-hydroxytryptamine receptors in the cranial vasculature. Cephalalgia. 1989;9 Suppl 9:15-22.|[2]Saxena PR, et al. From serotonin receptor classification to the antimigraine drug sumatriptan. Cephalalgia. 1992 Aug;12(4):187-96.|[3]Guscott MR, Egan E, Cook GP, Stanton JA, Beer MS, Rosahl TW, Hartmann S, Kulagowski J, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003 Jun;44(8):1031-7.|[4]Hurley PT, et al. Functional coupling of a recombinant human 5-HT5A receptor to G-proteins in HEK-293 cells. Br J Pharmacol. 1998 Jul;124(6):1238-44.|[5]Connor HE, et al. 5-Carboxamidotryptamine is a selective agonist at 5-hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats. Br J Pharmacol. 1986 Feb;87(2):417-26.

• Shipping Conditions:

  Room temperature