Mps1-IN-10

• CAS Number:

  2489220-49-5

• UNSPSC Description:

  Mps1-IN-10 (Compound 9) is an inhibitor for Mps1 with an IC50 of 6.4 nM. Mps1-IN-10 inhibits the proliferation of cancer cell MDA-MB-231 with a GI50 of 11 nM. Mps1-IN-10 exhibits anti-tumor efficacy in mice MDA-MB-231 xenograft models[1].

• Target Antigen:

  Mps1

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mps1-in-10.html

• Smiles:

  N#CC1=CNC2=NC(NC3=CC=C(N4C(CCC4)=O)C=C3OC)=NC(NC5CCCCC5)=C21

• Molecular Weight:

  445.52

• References & Citations:

  [1]Lee Y, et al., X-ray Crystal Structure-Guided Design and Optimization of 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J Med Chem. 2021 May 27;64(10):6985-6995.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported