PROTAC BRD9 Degrader-8

• UNSPSC Description:

  PROTAC BRD9 Degrader-8 (compound E5) is a PROTAC-based BRD9 degrader with a DC50 value of 16 pM. PROTAC BRD9 Degrader-8 has antiproliferation in MV4–11 cells (IC50 = 0.27 nM) and OCI-LY10 cells (IC50 = 1.04 nM)[1].

• Target Antigen:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/protac-brd9-degrader-8.html

• Smiles:

  O=C1C2=C(C(C3=CC(OC)=C(C(OC)=C3)CN4CCC(CN5CCC(CC5)C6=C7C(C8=CC=C7)=C(C=C6)N(C9C(NC(CC9)=O)=O)C8=O)CC4)=CN1C)C=CC=C2

• Molecular Weight:

  767.91

• References & Citations:

  [1]Haiting Duan, et al. Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors. J. Med. Chem. 2024, 67, 13, 11326–11353.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported