Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH

• Product Name Alternative:

  Cereblon Ligand-Linker Conjugates 14; E3 ligase Ligand-Linker Conjugates 49

• CAS Number:

  2351103-63-2

• UNSPSC Description:

  Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugates-49.html

• Purity:

  95.02

• Solubility:

  DMSO : 55 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=O)CCC1N(C2=O)C(C3=C2C(NCCNC(COCCCCCOCCOCCCCCOCC(O)=O)=O)=CC=C3)=O

• Molecular Weight:

  648.70

• References & Citations:

  [1]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Clinical Information:

  No Development Reported