Cetrorelix

Cetrorelix

• CAS Number: 120287-85-6
• UNSPSC Description: Cetrorelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice[1][2].
• Target Antigen: GnRH Receptor
• Type: Peptides
• Related Pathways: GPCR/G Protein
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Endocrinology
• Assay Protocol: https://www.medchemexpress.com/cetrorelix.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N(CCC1)[C@@H]1C(N[C@H](C)C(N)=O)=O)[C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](CCCNC(N)=O)NC([C@@H](NC([C@H](CO)NC([C@H](NC([C@H](NC([C@H](NC(C)=O)CC2=CC3=CC=CC=C3C=C2)=O)CC4=CC=C(Cl)C=C4)=O)CC5=CN=CC=C5)=O)=O)CC6=CC=C(O)C=C6)=O)=O)=O
• Molecular Weight: 1431.04
• References & Citations: [1]Diedrich K, et al. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod. 1994 May;9(5):788-91. |[2]Meirow D, et al. The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice. Hum Reprod. 2004 Jun;19(6):1294-9.
• Shipping Conditions: Room temperature
• Clinical Information: Launched