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Catenin, beta (p120)

CAT:
544-MBS439901-05
Size:
5x 0.1 mg (Without BSA at 1mg/mL)
Price:
Ask
For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Catenin, beta (p120) - image 1

Catenin, beta (p120)

  • Gene Name: [CTNNB1]
  • NCBI Gene ID: 1499
  • Reactivity: Human, Mouse, Rat. Others not known.
  • Storage Conditions: Antibody with azide - store at 2 to 8 °C.
    Antibody without azide - store at -20 to -80 °C.
    Antibody is stable for 24 months. Non-hazardous. No MSDS required.
  • Specificity: Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
  • Other Gene Names: [CTNNB1; CTNNB1; EVR7; CTNNB; MRD19; armadillo; CTNNB]
  • Short Name: [Catenin, beta]
  • Other Product Names: [catenin beta-1 isoform 1; Catenin beta-1; catenin beta-1; catenin beta 1; Beta-catenin]
  • NCBI GI Number: 148233338
  • NCBI Accession Number: NP_001091679.1
  • NCBI GB Accession Number: NM_001098209.1
  • Uniprot Accession Number: P35222