HLA-DRA (MHC II) Mouse Monoclonal Antibody

HLA-DRA (MHC II) Mouse Monoclonal Antibody

• CAS Number: 9007-83-4
• Gene Name: [HLA-DRA]
• NCBI Gene ID: 3122
• Reactivity: Human, Cow, Cat.
  Others not known
• Storage Conditions: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: This antibody detects a monomorphic general framework determinant of HLA-DR Class II antigen. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional AP's. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
• Other Gene Names: [HLA-DRA; HLA-DRA1]
• Short Name: [HLA-DRA]
• Other Product Names: [HLA class II histocompatibility antigen, DR alpha chain; HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA]
• NCBI GI Number: 52426774
• NCBI Accession Number: NP_061984.2
• NCBI GB Accession Number: NM_019111.4
• Uniprot Accession Number: P01903