MOUSE ANTI HUMAN SIGLEC-10

• CAS Number: 9007-83-4
• Gene Name: [SIGLEC-10]
• NCBI Gene ID: 89790
• Storage Conditions: Store at +4°C or at -20°C if prefered.
  Storage in forst-free freezers is not recommended.
  This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
• Specificity: SIGLEC-10
  Mouse anti Human Siglec-10 antibody, clone 5G6 recognises human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and membrane of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preerentially binds to glycoconjugates containing alpha-2,3- or alpha -2,6- linked sialic acid. Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on edothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Mouse anti Human Siglec-10 antibody, clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9.
• Other Gene Names: [SIGLEC10; SIGLEC10; SLG2; PRO940; SIGLEC-10; SLG2; Siglec-10]
• Short Name: [SIGLEC-10]
• Other Product Names: [sialic acid-binding Ig-like lectin 10 isoform 2; Sialic acid-binding Ig-like lectin 10; sialic acid-binding Ig-like lectin 10; sialic acid binding Ig-like lectin 10 Ig-like lectin 7; siglec-like gene 2; siglec-like protein 2; sialic acid binding Ig-like lectin 10; Siglec-like protein 2]
• NCBI GI Number: 283837876
• NCBI Accession Number: NP_001164627.1
• NCBI GB Accession Number: NM_001171156.1
• Uniprot Accession Number: Q96LC7