RAT ANTI MOUSE CD68:FITC

• CAS Number:

  9007-83-4

• Gene Name:

  [CD68]

• NCBI Gene ID:

  12514

• Storage Conditions:

  This product is shipped at ambient temperature.
  It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed and keep aliquots at 2-8°C for short term use (up to 4 weeks). Store the remaining aliquots at -20°C.
  
  Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

• Specificity:

  Rat anti Mouse CD68 antibody, clone FA-11 recognizes mouse macrosialin, a heavily glycosylated transmembrane protein and murine homolog of human CD68, which is classified as a unique scavenger receptor (ScR) family member, due to the presence of a lysosome associated membrane protein (LAMP)-like domain.
  CD68 is considered a pan macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes.
  CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used in cancer studies to demonstrate the presence/localization of macrophages.
  Rat anti mouse CD68 antibody, clone FA-11, has been used in many mouse models for the identification of CD68 in immunohistochemical studies, using both frozen and paraffin-embedded tissues (Masaki et al. 2003) and (Devey et al. 2009).
  Rat anti mouse CD68 antibody, clone FA-11 can be used in flow cytometry to detect intracellular CD68, following permeabilization, and can detect surface macrosialin at low levels in resident mouse peritoneal macrophages which can be enhanced with thioglycollate stimulation.

• Other Gene Names:

  [Cd68; Cd68; Lamp4; gp110; Scard1]

• Short Name:

  [CD68]

• Other Product Names:

  [Macrosialin; macrosialin; CD68 antigen; CD_antigen: CD68]

• NCBI GI Number:

  6753352

• NCBI Accession Number:

  NP_033983.1

• NCBI GB Accession Number:

  NM_009853.1