Recombinant Mouse IFN- Lambda3/IL-28B protein

• Background:

  Mouse IFN-lambda 2 (IL-28A), IFN-lambda 3 (IL-28B) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid sequence identity) and type I IFN family (15 - 19% a.a. sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28B shares 63%, 63%, and 52% a.a. identity with human IL-28A, IL-28B, and IL-29, respectively.

• CAS Number:

  9000-83-3

• Reconstitution:

  Lyophilized from a .2 μm filtered solution of 2mM PB, 15mM NaCl, pH 7.4.

• Molecular Weight:

  Approximately 19.6 kDa, a single non-glycosylated polypeptide chain containing 174 amino acids.