Recombinant Rhesus Macaque IP-10/CXCL10 protein

• Background:

  CXCL10 also known as IP-10 is belonging to the CXC chemokine family. It is encoded by the CXCL10 gene. CXCL10 was originally identified in monocytes, endothelial cells and fibroblasts as a responsor to IFN-γ. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes and monocytes/macrophages. It also has other roles, such as promotion of T cell adhesion to endothelial cells, and inhibition of bone marrow colony formation and angiogenesis. The rhesus macaque IP-10 shares 96 %, 68 %, 74 % a.a. sequence identity with human, Mouse, rat IP-10, respectively.

• CAS Number:

  9000-83-3

• Reconstitution:

  Lyophilized from a .2 μm filtered solution of PBS, pH 7.4.

• Molecular Weight:

  Approximately 8.7 kDa, a single non-glycosylated polypeptide chain containing 77 amino acids.