Recombinant Human CXCL10 (IP-10)

• Description:

  The ELR-negative CXC chemokine CXCL10 (IP-10) has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. Human CXCL10 Recombinant Protein is purified CXCL10 (IP-10) produced in yeast.

• Synonyms:

  Human ; CXCL10

• Label:

  ICT

• Type:

  Recombinant Protein

• Source:

  Yeast

• Sequence:

  VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP (77)

• Assay Protocol:

  The Mouse IP-10/CXCL10 protein can be used in cell culture, as an IP-10/CXCL10 ELISA Standard, and as a Western Blot Control.

• Form:

  Lyophilized

• Shipping Conditions:

  Shipping: Ships at ambient temperature, Ships overnight (domestic), International Priority Shipping

• Storage Temperature:

  -20°C

• Notes:

  20% discount

• Calculated Molecular Weight:

  8.6 kDa

• Target Description:

  C-X-C motif chemokine 10 (CXCL10), also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10, is a member of the C-X-C chemokine family and is closely related to two other CXC chemokines: CXCL9 and CXCL11., , There have been 17 different C-X-C chemokines described in mammals that are subdivided into two categories: those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. The ELR-negative chemokine CXCL10 (IP-10) elicits its effects by binding to the cell surface chemokine receptor CXCR3., , CXCL10 (IP-10) is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 (IP-10) has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.