Recombinant Mouse CXCL12

• Description:

  The C-X-C motif chemokine CXCL12 binds to one single chemokine receptor, CXCR4, to mediate cell-type specific physiological processes, including cellular migration, survival, and apoptosis. CXCL12 and its receptor CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis. Mouse CXCL12 Recombinant Protein is purified CXCL12 produced in yeast.

• Synonyms:

  Mouse ; CXCL12

• Label:

  ICT

• Type:

  Recombinant Protein

• Source:

  Yeast

• Sequence:

  GKPVSLSYRC PCRFFESHIA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKG RREEKVGKKE KIGKKKRQKK RKAAQKRKN (99)

• Assay Protocol:

  The Mouse BAFF protein can be used in cell culture, as a BAFF ELISA Standard, and as a Western Blot Control.

• Form:

  Lyophilized

• Shipping Conditions:

  Shipping: Ships at ambient temperature, Ships overnight (domestic), International Priority Shipping

• Storage Temperature:

  -20°C

• Notes:

  20% discount

• Calculated Molecular Weight:

  11.6 kDa

• Target Description:

  CXCL12 was originally described as a vital chemoattractant for B cells and monocytes. CXCL12, also known as interleukin-8, is unlike other chemokines in that it binds to one single chemokine receptor, CXCR4, which itself is recognized by no other chemokines. CXCL12 binds to its receptor CXCR4 to mediate cell-type specific physiological processes, including cellular migration, survival, and apoptosis. CXCL12 is produced physiologically in various tissues, and its receptor CXCR4 is expressed on various haematopoietic and non-haematopoietic cells. CXCL12 and CXCR4 are essential for life as mice deficient in either gene are unable to survive much past birth. CXCL12 and CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis.