AF/LE Purified Anti-Human CD274/PD-L1 Antibody

AF/LE Purified Anti-Human CD274/PD-L1 Antibody

• Background: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
• Synonyms: B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
• CAS Number: 9007-83-4
• Gene ID: 29126
• Swiss Prot: Q9NZQ7
• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b κ
• Conjugation: None (Purified antibody-Azide Free/Low endotoxin)
• Applications: FCM,Block,FA
• Concentration: 0.5 mg/mL
• Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
• Storage Conditions: Store at 2~8°C. Do not freeze.