AF/LE Purified Anti-Mouse CD274/PD-L1 Antibody

AF/LE Purified Anti-Mouse CD274/PD-L1 Antibody

• Background: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
• Synonyms: B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
• CAS Number: 9007-83-4
• Gene ID: 60533
• Swiss Prot: Q9EP73
• Host: Rat
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b κ
• Conjugation: None (Purified antibody-Azide Free/Low endotoxin)
• Applications: FCM,Block
• Concentration: 0.5 mg/mL
• Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
• Storage Conditions: Store at 2~8°C. Do not freeze.