Anti-Mesothelin/MSLN Antibody , Dylight550 Conjugate

Anti-Mesothelin/MSLN Antibody , Dylight550 Conjugate

• Background: Mesothelin, also known as MSLN or MPF, is a protein that in humans is encoded by the MSLN gene. This gene is mapped to 16p13.3. This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas.
• Description: Boster Bio Anti-Mesothelin/MSLN Antibody Picoband® catalog # PB9671. Tested in IHC applications. This antibody reacts with Mouse.
• Synonyms: Mesothelin;Pre-pro-megakaryocyte-potentiating factor;Megakaryocyte-potentiating factor;MPF;Mesothelin, cleaved form;Msln;Mes, Mpf;
• Gene Name: Mesothelin
• Gene ID: 56047
• UniProt: Q61468
• Host: Rabbit
• Reactivity: Mouse
• Cross Reactivity: No cross-reactivity with other proteins
• Immunogen: E.coli-derived mouse Mesothelin recombinant protein (Position: K308-L576). Mouse Mesothelin shares 58.4%% and 89.6% amino acid (aa) sequence identity with human and rat Mesothelin, respectively.
• Clonality: Polyclonal
• Tissue Specificity: Highly expressed in lung and heart. Expressed at low levels in spleen, liver, kidney and testis. Present in lung (at protein level). .
• Applications: IHC
• Purification: Immunogen affinity purified.
• Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
• Form: Lyophilized
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Function: Membrane-anchored forms may play a role in cellular adhesion. .
• Components: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• References & Citations: 1. Bera, T. K., Pastan, I. Mesothelin is not required for normal mouse development or reproduction. Molec. Cell. Biol. 20: 2902-2906, 2000. 2. Scholler, N., Fu, N., Yang, Y., Ye, Z., Goodman, G. E., Hellstrom, K. E., Hellstrom, I. Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma. Proc. Nat. Acad. Sci. 96: 11531-11536, 1999.
• Storage Conditions: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.
• Calculated Molecular Weight: 69423 MW
• Observed Molecular Weight: 54 kDa
• Fragment: Rabbit IgG
• Specificity: No cross reactivity with other proteins.
• Applications Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Mouse, By Heat
  
• Subcellular Location: Cell membrane ; Lipid-anchor, GPI-anchor . Golgi apparatus .
• Protein Name: Mesothelin