IL-6 Luciferase Reporter-NIH 3T3 Cell Line
CAT:
519-RC1016
Size:
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 mL of 90% FBS + 10% DMSO.
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
IL-6 Luciferase Reporter-NIH 3T3 Cell Line
- Description: The IL-6 Luciferase Reporter cell line is a stably transfected NIH 3T3 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the IL-6 promoter. As a pleiotropic cytokine, interleukin 6 (IL-6) has pro- and anti-inflammatory roles which is not only involved in normal functions of the immune system, hematopoiesis and metabolism but also involved in the pathogenesis of metabolic and cardiovascular diseases. IL-6 gene induction is generally regulated by several transcription factors that activate the consensus sequences in the IL-6 promoter region, which include AP-1, C/EBP-beta and NF-kB in response to various proinflammatory cytokines, growth factors, and pathogen-associated molecular patterns such as Toll-like receptor (TLR) ligands. The IL-6 induction by lipopolysaccharide (LPS), the TLR4 ligand, is shown in Figure 1.
- Gene Name: IL-6
- Applications: Functional Assay
- Components: Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO.
- Storage Conditions: Immediately upon receipt, store in liquid nitrogen.
- Applications Notes: Functional Assay, detecting the transcriptional activity of IL-6