Anti-Forkhead box protein O1 FOXO1 Antibody

Anti-Forkhead box protein O1 FOXO1 Antibody

• Background: FOXO1, also known as FKHR or ForkHead in Rhabdomyosarcoma, is a 70 kDa protein which is a ubiquitously expressed member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In insulin-responsive tissues, stress or nutrient abundance triggers phosphorylation by PKB/AKT, blocking nuclear translocation and activity. Genetic mutations involving FOXO1A are a cause of alveolar rhabdomyosarcoma (RMS2). Recent studies link the anti-tumor activity of FOXO1 and the process of autophagy.
• Description: Boster Bio Anti-Forkhead box protein O1 FOXO1 Antibody (Catalog # A00073). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
• Synonyms: FKH1, FKHR, FOXO1A, Forkhead box protein O1, Forkhead box protein O1A
• CAS Number: 9007-83-4
• Gene Name: FOXO1
• UniProt: Q12778
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Immunogen: FOXO1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human FOXO1. The immunogen is located within the first 50 amino acids of FOXO1.
• Clonality: Polyclonal
• Applications: ELISA, WB, ICC, IF
• Purification: FOXO1 Antibody is affinity chromatography purified via peptide column.
• Concentration: 1 mg/mL
• Form: Liquid
• Molecular Weight: 69662 MW
• Components: FOXO1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Storage Conditions: FOXO1 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
• Fragment: IgG