Anti-Bcl-10 Antibody
CAT:
519-A01616
Size:
0.1 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-Bcl-10 Antibody
- Background: Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-κB activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy. Bcl10 is expressed in many human and murine tissues and cell lines.
- Description: Boster Bio Anti-Bcl-10 Antibody (Catalog # A01616). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
- Synonyms: CLAP, mE10, CIPER, c-E10, CARMEN, CLAP, CARD-containing molecule enhancing NF-kappa-B, Bcl-10
- CAS Number: 9007-83-4
- Gene Name: BCL10
- UniProt: O95999
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Immunogen: Bcl10 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Bcl10. The immunogen is located within the first 50 amino acids of Bcl-10.
- Clonality: Polyclonal
- Applications: ELISA, WB, ICC, IF
- Purification: Bcl-10 Antibody is affinity chromatography purified via peptide column.
- Concentration: 1 mg/ml
- Form: Liquid
- Molecular Weight: 26252 MW
- Components: Bcl-10 Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage Conditions: Bcl-10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Fragment: IgG