Recombinant Human IL-7 Receptor Subunit alpha/IL-7RA/CD127 (C-6His)

• Background:

  Interleukin 7 Receptor alpha (IL-7Rα), also known as CD127, is a 75 kDa hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7Rα is majorly expressed on T cells and their precursors, and early in B cell development as well, prior to the appearance of surface IgM. Dynamic regulation of IL-7Rα is important for the generation of appropriate immune responses.

• Abbreviation:

  IL-7RA, CD127

• Synonyms:

  CDW; IL7R; CD127; CDW127; IL-7R-alpha; IL7RA; ILRA; IL-7R; IL-7RA; IL-7Rα; Interleukin-7 receptor subunit alpha; IL-7R& alpha; CD 127; CD127 antigen; IL 7R; IL 7R alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL7Ralpha; Interleukin 7 receptor; Interleukin 7 receptor alpha chain; Interleukin 7 receptor isoform H5 6

• UniProt:

  P16871

• Accession Number:

  P16871

• Expression System:

  HEK293 Cells

• Tag:

  C-His

• Sequence:

  Glu21-Gly236

• Field of Research:

  Immunology; Stem cells

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  25.7 kDa

• Observed Molecular Weight:

  40 - 55 kDa

• Formulation:

  Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
  Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
  Please refer to the specific buffer information in the printed manual.

• Species:

  Human