Recombinant Human CEACAM5/CD66e/CEA (C-6His-Avi) Biotinylated

• Background:

  Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell–cell recognition. CEACAM5, also called CEA and CD66e, is characterized by having seven extracellular Ig domains and a glycosylphosphatidylinositol (GPI) anchor. CEACAM5 is expressed primarily by epithelial cells, and functions as a calcium-independent adhesion molecule through homophilic and heterophilic interactions with CEACAM1. Studies have shown that CEACAM5 is overexpressed in a majority of carcinomas, and its overexpression can protect tumor cells from apoptosis. It is commonly used as a cancer marker.

• Abbreviation:

  CEACAM5, CD66e, CEA

• Synonyms:

  CD66e; CEA; CEACAM5; Carcinoembryonic antigen; Carcinoembryonic antigen-related cell adhesion molecule 5; Meconium antigen 100

• UniProt:

  P06731

• Accession Number:

  P06731

• Expression System:

  HEK293 Cells

• Conjugation:

  Biotinylated

• Tag:

  C-His-Avi

• Sequence:

  Lys35-Ala685

• Field of Research:

  Tags & Cell Markers; Microbiology; Cancer; immunology; Stem cells

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  74.2 kDa

• Observed Molecular Weight:

  110 - 150 kDa

• Formulation:

  Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
  Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
  Please refer to the specific buffer information in the printed manual.

• Species:

  Human