Recombinant Human FGL1 (C-Fc-Avi) Biotinylated

• Background:

  Fibrinogen-like protein 1 (FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3 .
• Abbreviation:

  FGL1
• Synonyms:

  FGL1; Fibrinogen-like protein 1; HFREP-1; HP-041; Hepassocin; LFIRE-1
• UniProt:

  Q08830
• Accession Number:

  Q08830
• Expression System:

  HEK293 Cells
• Conjugation:

  Biotinylated
• Tag:

  C-Fc-Avi
• Sequence:

  Leu23-Ile312
• Field of Research:

  Cardiovascular
• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity:

  > 90 % as determined by reducing SDS-PAGE.
• Bioactivity:

  Not validated for activity
• Reconstitution:

  Please refer to the printed manual for detailed information.
• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Calculated Molecular Weight:

  62.7 kDa
• Observed Molecular Weight:

  60 kDa
• Formulation:

  Lyophilized from a 0.2 µm filtered solution of PBS, 5% Trehalose, pH 7.4.
  Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
  Please refer to the specific buffer information in the printed manual.
• Species:

  Human