Recombinant Human BCL6/B-cell CLL lymphoma 6 Protein (aa 1-150, His & Trx Tag)

Recombinant Human BCL6/B-cell CLL lymphoma 6 Protein (aa 1-150, His & Trx Tag)

• Background: The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.
• Synonyms: BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
• CAS Number: 9000-83-3
• UniProt: P41182
• Accession Number: P41182
• Host: E. coli
• Origin Species: Human
• Tag: N-Trx-His
• Sequence: Met 1-Met 150
• Field of Research: Cancer;epigenetics and nuclear signal
• Purity: > 92 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 33 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.