Alpha-Estradiol

• CAS Number:

  57-91-0

• UNSPSC Description:

  Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

• Target Antigen:

  5 alpha Reductase; Bacterial; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Alpha-Estradiol.html

• Purity:

  99.88

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 11.11 mg/mL (ultrasonic)

• Smiles:

  C[C@@]12[C@H](O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC2

• Molecular Weight:

  272.388

• References & Citations:

  [1]Schriefers H, et al. Inhibition of testosterone metabolism by 17-alpha-estradiol in rat liver slices. Arzneimittelforschung. 1991 Nov;41(11):1186-9.|[2]Santos RS, et al. The effects of 17 alpha-estradiol to inhibit inflammation in vitro. Biol Sex Differ. 2017 Sep 6;8:30.|[3]Zhang HB, et al. 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model. Jpn J Ophthalmol. 2012 Jul;56(4):407-15.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched