TP-5801

• CAS Number:

  2574474-81-8

• UNSPSC Description:

  TP-5801 is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor (IC50=1.40 nM), and shows anti-tumor activity[1].

• Target Antigen:

  STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tp-5801.html

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles:

  CN1CCN(C2=C(C)C=C(NC3=NC=C(Br)C(NC4=CC=CN=C4N(C)C)=N3)C(OC)=C2)CC1

• Molecular Weight:

  527.46

• References & Citations:

  [1]Tsz-Yin Chan, et al. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nat Commun. 2021 Sep 9;12(1):5337.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported