Mouse Anti-Human XEDAR protein Monoclonal Antibody

Mouse Anti-Human XEDAR protein Monoclonal Antibody

• Description: Tumor necrosis factor receptor superfamily member 27 is a protein that in humans is encoded by the EDA2R gene. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Multiple alternatively spliced transcript variants have been found for this gene, but some variants lack sufficient support.
• Synonyms: ectodysplasin A2 receptor, EDA2R, EDA-A2 receptor, tumor necrosis factor receptor superfamily member XEDAR, X-linked ectodysplasin-A2 receptor
• CAS Number: 9007-83-4
• NCBI Gene ID: 60401
• UniProt: Q9HAV5
• Accession Number: NP_001186616.1
• Accession Number mRNA: NM_001199687.2
• Host: Mouse
• Origin Species: Human
• Species Reactivity: Human
• Target Antigen: Human Recombinant XEDAR protein
• Isotype: IgG1
• Clone: (#2L23)
• Validated Applications: WB, N, B
• Purification Method: Protein G chromatography
• Form: Lyophilized
• Buffer: PBS
• Reconstitution: Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.