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Leptin Recombinant Protein

CAT:
209-R20-033S
Size:
200 µg
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Leptin Recombinant Protein - image 1

Leptin Recombinant Protein

  • Description: Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Rat Leptin is a 16.2 kDa protein containing 147 amino acid residues.
  • Synonyms: Lep; ob; obese
  • CAS Number: 9000-83-3
  • NCBI Gene ID: 25608
  • UniProt: P50596
  • Accession Number: NP_037208
  • Accession Number mRNA: NM_013076
  • Gene Location: 4q22
  • Host: E. coli
  • Origin Species: Rat
  • Species Reactivity: Mouse, Rat
  • Sequence: MVPIHKVQDD TKTLIKTIVT RINDISHTQS VSARQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQILTSLP SQNVLQIAHD LENLRDLLHL LAFSKSCSLP QTRGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDLSPEC
  • Detection Range: Determined by an in vivo assay using the ob/ob mouse obesity model and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5µg leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.
  • Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
  • Purity: > 98% by SDS-PAGE & HPLC analyses
  • Length: 147
  • Form: Lyophilized
  • Molecular Weight: 16.2 kDa
  • Shipping Conditions: Room Temperature