Ganoderic acid T1

Ganoderic acid T1

• UNSPSC Description: Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity[1].
• Target Antigen: Apoptosis; Caspase
• Type: Natural Products
• Related Pathways: Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ganoderic-acid-t1.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@]12C3=CCC4C([C@H](OC(C)=O)CC[C@@]4(C3=CC[C@]1(C)C([C@@H]([C@H](C/C=C(C(O)=O)\C)O)C)C[C@@H]2OC(C)=O)C)(C)C
• Molecular Weight: 570.76
• References & Citations: [1]Liu RM, et al. Structurally related ganoderic acids induce apoptosis in human cervical cancer HeLa cells: Involvement of oxidative stress and antioxidant protective system. Chem Biol Interact. 2015 Oct 5;240:134-44.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported