Camostat mesylate

Camostat mesylate

• Background: Camostat mesylate is an orally active protease inhibitor. It inhibits the serine protease TMPRSS2 and partially blocks entry of SARS-Cov-2 (Covid-19) into lung cells and Human coronavirus NL63 into HeLa cells. It has also been used in some cancer treatments, against viral infections, and for inhibiting fibrosis in liver, kidney disease and pancreatitis.
• Description: Serine protease inhibitor
• Product Name Alternative: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate; FOY 305; FOY-S 980; Foipan mesylate
• CAS Number: 59721-29-8
• UNSPSC: 41116105
• Source: Synthetic
• Purity: >98% (HPLC); NMR (Conforms)
• Weight: 0.005
• Format: Off-white powder
• Solubility: May be dissolved in DMSO (50 mg/mL) or Water (50mg/mL)
• Molecular Formula: C20H22N4O5·CH3SO3H
• Molecular Weight: 494.5
• Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• References & Citations: 1. Okuno M., et al. (2002). Front Biosci. 7 (4): d204-218. 2. Hsieh H. P., Hsu, J. T. (2007). Current Pharmaceutical Design. 13 (34): 3531–3542. 3. Kitamura K., Tomita K. (2012). Clinical and Experimental Nephrology. 16 (1): 44–48. 4. Kawase M., Shirato K., van der Hoek L., Taguchi F., Matsuyama S. (2012) J Virol. 86(12): 6537-6545. 5.. Hoffman M., et al. (2020) Cell: https://doi.org/10.1016/j.cell.2020.02.052