Human Complement Factor D / CFD Protein, His Tag (active enzyme)

• Background:

  Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.

• Description:

  Human Complement Factor D, His Tag (CFD-H52H8) is expressed from human 293 cells (HEK293) and active. It contains AA Ile 26 - Ala 253 (Accession # P00746-1) .

• Specifications:

  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 28 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

• Accession Number:

  P00746-1

• Expression Region:

  Ile 26 - Ala 253

• Host:

  HEK293

• Target:

  Complement Factor D

• Conjugation:

  Unconjugated

• Tag:

  C-10xHis

• Source:

  Human

• Stability:

  ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

• Endotoxin:

  1.0 EU per μg

• Purity:

  95%

• Format:

  Powder

• Buffer:

  50 mM Tris, 150 mM NaCl, pH8.0

• Additives:

  Glycerol

• Molecular Weight:

  26.3 kDa

• Shipping Conditions:

  RT

• Storage Conditions:

  -20°C

• Package Size:

  50ug*1

• Species:

  Human