(R)-Citalopram (oxalate)

• CAS Number:

  219861-53-7

• UNSPSC Description:

  (R)-Citalopram oxalate is an anticonvulsant, antidepressant and muscle relaxant. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (Escitalopram; HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate functionally antagonises S-citalopram in vivo and in vitro. (R)-Citalopram oxalate has an effect on the association of Escitalopram with the high affinity primary site, and on its dissociation from the 5-HT transporter, via an allosteric mechanism[1].

• Target Antigen:

  5-HT Receptor; Serotonin Transporter

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/r-citalopram-oxalate.html

• Purity:

  99.52

• Solubility:

  DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  OC(C(O)=O)=O.CN(C)CCC[C@@]1(C2=CC=C(C=C2)F)C3=CC=C(C#N)C=C3CO1

• Molecular Weight:

  414.43

• References & Citations:

  [1]Signe í Stórustovu, et al. R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter.  Br J Pharmacol. 2004 May;142(1):172-80.|[2]Connie Sánchez, et al.  The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of S-citalopram. Basic Clin Pharmacol Toxicol. 2006 Aug;99(2):91-5.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported